The growth of tourism in the Mediterranean, especially in coastal areas, and the effects of climate change will continue to affect landscapes, soil and coasts stability/erosion, put pressure on species and water resources, and increase waste and pollution discharges into the sea. In this context, the Co-Evolve4BG project aims at analyzing and promoting the co-evolution of human activities and natural eco-systems in touristic coastal areas, towards sustainable development of tourist activities based on the principles of Integrated Coast Zone Management (ICZM) and Maritime Spatial Planning (MSP), promoting at the same time Blue Growth in the Mediterranean. The analysis and the demonstration actions foreseen by the project will enhance sustainable coastal and maritime tourism development fully exploiting the Blue Economy potential, promoting the creation of business and job opportunities in the field of ecosystem-oriented services, coastal and maritime tourism, coastal management and adaptation to climate change. Co-Evolve4BG will take advantage from the methodology of the CO-EVOLVE project that was funded by the Interreg MED Programme and extend its main actions towards the South & East Mediterranean through the integration of new pilot areas. Finally, Co-Evolve4BG is part of a wider project, “Med Coast for Blue Growth” labelled by the 43 Countries of the Union for the Mediterranean.